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Article

KPC-33 and ompK37 mutations: Unraveling the mechanism of ceftazidime/avibactam resistance in ST11 carbapenem-resistant Klebsiella pneumoniae.

PloS one - 1 Jan 2026

Zhao Shulong, Ye Lin, Song Shuang, Sun Jingfang, Xu Jinfeng, Jiang Fei, Kang Haiquan

Abstract excerpt

BACKGROUND: Global surveillance indicates rising ceftazidime-avibactam resistance among carbapenem-resistant Klebsiella pneumoniae (CRKP), with sequence type 11 predominating in China. The contribution of blaKPC variants and porin alterations to high-level resistance remains significant. METHODS: We employed whole-genome sequencing and functional analyses to characterise a CZA-resistant ST11 CRKP isolate...

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Identifiers

PMID: 41770798
DOI: 10.1371/journal.pone.0342729
PMCID: PMC12952571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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