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Article

Dynamic evolution of ceftazidime-avibactam resistance from a single patient through the IncX3_NDM-5 plasmid transfer and blaKPC mutation.

International journal of antimicrobial agents - 1 Aug 2024

Tang Chengkang, Shen Siquan, Yang Weiwei, Shi Qingyu, Ding Li, Han Renru, Hu Fupin

Abstract excerpt

The rapid dissemination of carbapenem-resistant Enterobacterales (CRE) especially carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a great threat to global public health. Ceftazidime-avibactam, a novel β-lactam/β-lactamase inhibitor combination, has been widely used due to its excellent antibacterial activity against KPC-producing K. pneumoniae. However, several resistance mechanisms have been reported...

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PMID: 38823494
DOI: 10.1016/j.ijantimicag.2024.107228

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