Transcriptomic and metabolomic profiles reveal the functions of IGF-1 c.258 A > G synonymous mutation in milk fat content.

doi:10.1016/j.jare.2025.06.086

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Article

Transcriptomic and metabolomic profiles reveal the functions of IGF-1 c.258 A > G synonymous mutation in milk fat content.

Journal of advanced research - 1 Apr 2026

Fang Jiayuan, Zheng Shuo, Zhang Xunming, Chen Xi, Li Yi, Zhang Libo, Xiao Xingyu, Cheng Yunyun, Xu Yuanyuan, Hao Linlin

Abstract excerpt

INTRODUCTION: Previous studies have reported that IGF-1 single nucleotide polymorphism is associated with milk fat traits, but they are limited to trait association analysis. We previously identified a synonymous mutation c.258 A > G (rs322131043) in IGF-1, which influenced IGF-1 expression and caused differences in metabolism. OBJECTIVES: This study aims to reveal a new regulatory function of IGF-1 c.258 A > G...

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PMID: 40588029
DOI: 10.1016/j.jare.2025.06.086
PMCID: PMC13000935

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