Complexity of the neutrophil transcriptome in early and severe rheumatoid arthritis: a role for microRNAs?

Abstract excerpt

Neutrophils are innate immune cells that drive the progression of rheumatoid arthritis through the release of reactive oxygen species, neutrophil extracellular traps, and proteases that damage host tissues. Neutrophil activation is regulated, in part, by dynamic changes in gene expression. In this study, we have used RNAseq to measure the transcriptomes of neutrophils from people with severe,...

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