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Neutrophil activation signature in juvenile idiopathic arthritis indicates the presence of low-density granulocytes

7 Dec 2017

Abstract excerpt

Objective: JIA is an autoimmune, inflammatory disease with involvement of innate and adaptive immune responses. However, the role of neutrophils in JIA pathogenesis remains unclear. This study aimed to identify and validate neutrophil gene expression signatures in JIA using public microarray datasets and new clinical samples. Methods: Three suitable datasets were analysed by significance analysis of microarray...

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PMID: 29240923
DOI: 10.1093/rheumatology/kex441

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