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Interferon gene expression signature in rheumatoid arthritis neutrophils correlates with a good response to TNFi therapy

13 Aug 2014

Abstract excerpt

OBJECTIVE: The aim of this study was to use whole transcriptome sequencing (RNA-Seq) of RA neutrophils to identify pre-therapy gene expression signatures that correlate with disease activity or response to TNF inhibitor (TNFi) therapy. METHODS: Neutrophils were isolated from the venous blood of RA patients (n = 20) pre-TNFi therapy and from healthy controls (n = 6). RNA was poly(A) selected and sequenced on the...

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PMID: 25125592
DOI: 10.1093/rheumatology/keu299

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