Article
Cyclic Di-AMP Affects Cell Membrane Integrity of Streptococcus pneumoniae.
Molecular microbiology - 1 Sept 2025
Zarrella Tiffany M, Gao Jianle, Forrest Nathan, Crosbourne Elijah, Cui Kaibo, Bai Guangchun
Abstract excerpt
Competence is an important bioprocess for Streptococcus pneumoniae. Previously, we demonstrated that the bacterial second messenger cyclic di-adenosine monophosphate (c-di-AMP) modulates pneumococcal competence. Surprisingly, cdaA*, a strain producing less c-di-AMP due to a point mutation in the diadenylate cyclase CdaA, is susceptible to competence-stimulating peptide (CSP). In this study, we screened cdaA*...
Topics
- Streptococcus pneumoniae
- Cell Membrane
- Bacterial Proteins
- Dinucleoside Phosphates
- Gene Expression Regulation, Bacterial
- Promoter Regions, Genetic
- Transcription Factors
- Mutation
- Phosphoric Diester Hydrolases
- Cyclic AMP