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Article

Cyclic Di-AMP Affects Cell Membrane Integrity of Streptococcus pneumoniae.

Molecular microbiology - 1 Sept 2025

Zarrella Tiffany M, Gao Jianle, Forrest Nathan, Crosbourne Elijah, Cui Kaibo, Bai Guangchun

Abstract excerpt

Competence is an important bioprocess for Streptococcus pneumoniae. Previously, we demonstrated that the bacterial second messenger cyclic di-adenosine monophosphate (c-di-AMP) modulates pneumococcal competence. Surprisingly, cdaA*, a strain producing less c-di-AMP due to a point mutation in the diadenylate cyclase CdaA, is susceptible to competence-stimulating peptide (CSP). In this study, we screened cdaA*...

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Identifiers

PMID: 40576446
DOI: 10.1111/mmi.70003
PMCID: PMC12354235

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