Article
Pooled, Long-read Sequencing for Structural Variant Characterization in Schistosome Populations.
Genome biology and evolution - 3 Jul 2025
Nair Shalini, Li Xue, Anderson Timothy J C, Platt Roy N
Abstract excerpt
Pooled sequencing provides a rapid cost-effective approach to assess genetic variation segregating within populations of organisms. However, such studies are typically limited to single nucleotide variants and small indels (≤50 bp), and have not been used for structural variants (SVs > 50 bp) which impact large portions of most genomes and may significantly impact phenotype. Here, we examined SVs circulating in...
Topics
- Animals
- Schistosoma mansoni
- Genomic Structural Variation
- Genome, Helminth
- Genetic Variation
- Humans
- Sequence Analysis, DNA