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Article

Abundant genetic variation is retained in many laboratory schistosome populations.

PLoS pathogens - 1 Aug 2025

Jutzeler Kathrin S, Platt Roy N, Diaz Robbie, Morales Madison, Dunning Hotopp Julie, Le Clec'h Winka, Chevalier Frédéric D, Anderson Timothy J C

Abstract excerpt

Schistosomes are obligately sexual blood flukes that can be maintained in the laboratory using freshwater snails as intermediate and rodents as definitive hosts. The genetic composition of laboratory schistosome populations is poorly understood: whether genetic variation has been purged due to serial inbreeding or retained is unclear. We sequenced 19 - 24 parasites from each of five laboratory Schistosoma mansoni...

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Topics

Animals
Genetic Variation
Schistosoma mansoni
Schistosomiasis mansoni
Linkage Disequilibrium
Genome, Helminth

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Identifiers

PMID: 40834030
DOI: 10.1371/journal.ppat.1013439
PMCID: PMC12377630

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