The relationship of NOS3 G894 T (rs1799983) gene polymorphism in the risk of congenital heart disease: a meta-analysis and bioinformatics study.

doi:10.1007/s00210-025-04252-2

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The relationship of NOS3 G894 T (rs1799983) gene polymorphism in the risk of congenital heart disease: a meta-analysis and bioinformatics study.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Dec 2025

Guo Tao, Meng Bao-Wei, Jin Gang, Liu Jia-Wei, Yi Kang, He Shao-E, Zhang Xin, Xu Jian-Guo, Xu Yu-Xin, You Tao

Abstract excerpt

Nitric Oxide Synthase 3 (NOS3) G894 T (rs1799983) is an important regulator of cardiac development. Its role in congenital heart disease (CHD) has been extensively studied in recent years, but the results are contradictory. The aim of the present study was to better elucidate the relationship between the NOS3 G894 T gene polymorphism and susceptibility of CHD and its specific subtypes. A comprehensive literature...

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PMID: 40571825
DOI: 10.1007/s00210-025-04252-2

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