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Article

LncRNA-536 and RNA-Binding Protein RBM25 Interactions in Pulmonary Artery Smooth Muscle Cells: Implications in Pulmonary Hypertension.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2025

Mahajan Aatish, Chandran Sivasankar, Kumar Ashok, Chen Ling, Dhillon Navneet K

Abstract excerpt

BACKGROUND: In this study, we define the mechanistic association between long noncoding RNA: ENST00000495536 (lnc-536) and transcription factor HOXB13 (homeobox B13) in mediating proproliferative smooth muscle phenotype associated with pulmonary hypertension. METHODS: In vitro knockdown or knockin, along with RNA pull-down and immunoprecipitation studies, were used to evaluate the role of lnc-536 and HOXB13 in...

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Topics

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Share to Hypertension, Pulmonary
Share to Muscle, Smooth, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocytes, Smooth Muscle

Share to Pulmonary Artery

Share to Rats, Sprague-Dawley

Share to RNA-Binding Proteins

Share to RNA, Long Noncoding

Share to Vascular Remodeling

Source

Open in PubMed Open full text

Identifiers

PMID: 40567228
DOI: 10.1161/ATVBAHA.125.322734
PMCID: PMC12286719

Genes

HOXB13
RBM25
SFPQ
PAH
TEAD4
VGLL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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