Germline mutations predisposing to melanoma.

Abstract excerpt

Nearly 15% of melanomas occur in patients with a family history and a subset of these patients have a germline mutation in a melanoma predisposing gene. CDKN2A mutations are responsible for the majority of hereditary melanoma, but many other susceptibility genes have been discovered in recent years, including CDK4, TERT, ACD, TERF2IP, POT1, MITF, MC1R, and BAP1. Additionally, melanoma risk is increased in mixed...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cyclin-Dependent Kinase 4
• Share to Genes, p16
• Share to Microphthalmia-Associated Transcription Factor