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Article

HLA Class I Genotype Is Associated with Relapse Risk after Allogeneic Stem Cell Transplantation for NPM1-Mutated Acute Myeloid Leukemia.

Transplantation and cellular therapy - 1 Jul 2023

Narayan Rupa, Niroula Abhishek, Wang Tao, Kuxhausen Michelle, He Meilun, Meyer Everett, Chen Yi-Bin, Bhatt Vijaya Raj, Beitinjaneh Amer, Nishihori Taiga, Sharma Akshay, Brown Valerie I, Kamoun Malek, Diaz Miguel A, Abid Muhammad Bilal, Askar Medhat, Kanakry Christopher G, Gragert Loren, Bolon Yung-Tsi, Marsh Steven G E, Gadalla Shahinaz M, Paczesny Sophie, Spellman Stephen, Lee Stephanie J

Abstract excerpt

Mutation-bearing peptide ligands from mutated nucleophosmin-1 (NPM1) protein have been empirically found to be presented by HLA class I in acute myeloid leukemia (AML). We hypothesized that HLA genotype may impact allogeneic hematopoietic stem cell transplantation (allo-HCT) outcomes in NPM1-mutated AML owing to differences in antigen presentation. We evaluated the effect of the variable of predicted strong...

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Identifiers

PMID: 36997024
DOI: 10.1016/j.jtct.2023.03.027
PMCID: PMC10330307

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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