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Article

GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma

18 Aug 2020

Abstract excerpt

was observed in most cisplatin nonresponder cases. Silencing of GULP1 was associated with GULP1 promoter hypermethylation in cell lines and primary tumors, and a high frequency of GULP1 promoter methylation was observed in multiple sets of primary clinical UCB samples. Together, our findings demonstrate that GULP1 is a KEAP1-binding protein that regulates KEAP1-NRF2 signaling in UCB and that promoter...

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PMID: 32817372
DOI: 10.1126/scisignal.aba0443

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