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Article

Effects of novel HDAC inhibitors on urothelial carcinoma cells

31 Jul 2018

Abstract excerpt

BACKGROUND: Histone deacetylase inhibitors (HDACi) are promising anti-cancer drugs that could also be employed for urothelial carcinoma (UC) therapy. It is unclear, however, whether inhibition of all 11 zinc-dependent HDACs or of individual enzymes is more efficacious and specific. Here, we investigated the novel HDACi 19i (LMK235) with presumed preferential activity against class IIA HDAC4/5 in comparison to the...

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PMID: 30064501
DOI: 10.1186/s13148-018-0531-y

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