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Article

Establishing the Frequency of the HLA Class II Pseudotumour 'at Risk' Genotype: A Pilot Epidemiologic Analysis.

ANZ journal of surgery - 1 Oct 2025

Kurmis Andrew P, Kurmis Kimberley F

Abstract excerpt

PURPOSE: Immune-mediated adverse local tissue reactions (ALTRs) to implanted metallic devices are an increasingly recognised orthopaedic concern. Recent research has identified a critical HLA genotype associated with increased risk of ALTR development around in situ arthroplasty implants. Carriage imparts a > 700% increased relative-risk of high-grade peri-prosthetic lesion development, associated with pain and...

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Identifiers

PMID: 40548482
DOI: 10.1111/ans.70232
PMCID: PMC12571935

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