Article
Frank Stinchfield Award: Identification of the At-risk Genotype for Development of Pseudotumors Around Metal-on-metal THAs.
Clinical orthopaedics and related research - 1 Feb 2018
Kilb Brett K J, Kurmis Andrew P, Parry Michael, Sherwood Karen, Keown Paul, Masri Bassam A, Duncan Clive P, Garbuz Donald S
Abstract excerpt
BACKGROUND: Once touted as the future of hip arthroplasty, metal-on-metal (MoM) bearing surfaces have fallen sharply from favor with the emergence of a strong body of evidence demonstrating unacceptably high premature implant failure rates. The previously unpredictable development of adverse local tissue reactions (ALTRs) has been a substantive contributor to this. Although the underlying pathophysiology of these...
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