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The influence of HLA genotype on the development of metal hypersensitivity following joint replacement

24 Jun 2022

Abstract excerpt

Background: Over five million joint replacements are performed across the world each year. Cobalt chrome (CoCr) components are used in most of these procedures. Some patients develop delayed-type hypersensitivity (DTH) responses to CoCr implants, resulting in tissue damage and revision surgery. DTH is unpredictable and genetic links have yet to be definitively established. Methods: At a single site, we carried...

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PMID: 35761834
DOI: 10.1038/s43856-022-00137-0

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