Article
Progresses Toward Precision Medicine in RET-altered Solid Tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2020
Belli Carmen, Anand Santosh, Gainor Justin F, Penault-Llorca Frederique, Subbiah Vivek, Drilon Alexander, Andrè Fabrice, Curigliano Giuseppe
Abstract excerpt
RET (rearranged during transfection) gene encodes a receptor tyrosine kinase essential for many physiologic functions, but RET aberrations are involved in many pathologies. While RET loss-of-function mutations are associated with congenital disorders like Hirschsprung disease and CAKUT, RET gain-of-function mutations and rearrangements are critical drivers of tumor growth and proliferation in many different...
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