Article
Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis.
Molecular neurodegeneration - 20 Jun 2025
Ziff Oliver J, Parfitt Gustavo Morrone, Jolly Sarah, Casey Jackie M, Granat Lucy, Samra Satinder, Setó-Salvia Núria, Alatza Argyro, Phadke Leela, Galet Benjamin, Ravassard Philippe, Potier Marie-Claude, Hardy John, Salih Dervis A, Whiting Paul, Ducotterd Fiona, Patani Rickie, Wray Selina, Arber Charles
Abstract excerpt
BACKGROUND: Mutations in PSEN1 cause familial Alzheimer's disease with almost complete penetrance. Age at onset is highly variable between different PSEN1 mutations and even within families with the same mutation. Current research into late onset Alzheimer's disease implicates inflammation in both disease onset and progression. PSEN1 is the catalytic subunit of γ-secretase, responsible for regulated intramembrane...
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