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Article

Genomic Profiling of Indian Gallbladder Carcinoma: Mutational Insights in a High-Incidence Population.

JCO global oncology - 1 Dec 2025

Suryavanshi Moushumi, Ostwal Vikas, Javle Milind M, Kumar Manoj, Shetty Omshree, Patil Darshana, Sharma Shivani, Limaye Sewanti, Patel Amol, Sirohi Bhawna, Bahl Ankur, Rohtagi Nitesh

Abstract excerpt

PURPOSE: Gallbladder carcinoma (GBC) has a disproportionately high incidence rate in India; however, genomic data remain sparse and inconsistent. We conducted a comprehensive genomic analysis of Indian GBC and compared its mutational profile with that of international cohorts to identify region-specific oncogenic drivers. MATERIALS AND METHODS: This retrospective study analyzed 376 patients with GBC (339 tissue...

Read the complete abstract on PubMed

Topics

Humans
Gallbladder Neoplasms
Female
Male
Middle Aged
India

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Retrospective Studies

Mutation

Aged

Adult

Incidence

Genomics

High-Throughput Nucleotide Sequencing

Aged, 80 and over

Source

Identifiers

PMID: 41418080
DOI: 10.1200/GO-25-00332

Genes

CDKN2A
ERBB2
SMAD4
ARID1A
KRAS
TP53

Variants

Provenance

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