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An Engineered Paper-Based 3D Coculture Model of Pancreatic Cancer to Study the Impact of Tissue Architecture and Microenvironmental Gradients on Cell Phenotype.

Advanced healthcare materials - 1 Jun 2023

Cadavid Jose L, Latour Simon, Nowlan Ferris, Co Ileana L, Landon-Brace Natalie, Wouters Bradly G, Grünwald Barbara T, Nitz Mark, Jackson Hartland Warren, McGuigan Alison P

Abstract excerpt

The spatial configuration of cells in the tumor microenvironment (TME) affects both cancer and fibroblast cell phenotypes contributing to the clinical challenge of tumor heterogeneity and therapeutic resistance. This is a particular challenge in stroma-rich pancreatic ductal adenocarcinoma (PDAC). Here, a versatile system is described to study the impact of tissue architecture on cell phenotype using PDAC as a...

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Identifiers

PMID: 36308030
DOI: 10.1002/adhm.202201846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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