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Article

Longitudinal associations between self-reported exercise levels and cognition in ADAD.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2025

Sewell Kelsey R, Doecke James D, Martins Ralph N, Rainey-Smith Stephanie R, Peiffer Jeremiah, Gardener Samantha L, Sohrabi Hamid R, Erickson Kirk I, Brown Belinda M

Abstract excerpt

INTRODUCTION: This study examined longitudinal associations between self-reported exercise and cognition, with moderation by sex, in individuals with autosomal dominant Alzheimer's disease (ADAD) mutations. We also examined whether changes in exercise over time differed in ADAD mutation carriers versus non-carriers in the years preceding first cognitive symptom onset. METHODS: Participants (n = 491) were ADAD...

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Identifiers

PMID: 40534311
DOI: 10.1002/alz.70383
PMCID: PMC12177227

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