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Article

Prognostic Impact and Recurrence Pattern of KRAS G12C Mutation in Surgically Resected Non-Small Cell Lung Cancer.

The Annals of thoracic surgery - 1 Jan 2026

Wen Jialiang, Dong Yichen, Chen Tao, Wu Junqi, Zhong Yifan, Xu Long, Si Haojie, Huang Shenghao, Hou Likun, She Yunlang, Xie Dong, Chen Chang

Abstract excerpt

BACKGROUND: The effect of KRAS mutant subtypes on the outcome and recurrence pattern of patients with nonadvanced lung cancer remains controversial. This study aimed to broadly elucidate the oncologic characteristics of G12C mutation in resected non-small cell lung cancer (NSCLC). METHODS: A total of 18,509 stage I-III NSCLC patients who received surgical resection and genetic assay were retrospectively enrolled....

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PMID: 40532941
DOI: 10.1016/j.athoracsur.2025.04.040

Genes

KRAS

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