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Article

Prevalence and spectrum of germline BRCA1 and BRCA2 mutations in multiethnic cohort of breast cancer patients in Brunei Darussalam.

PloS one - 1 Jan 2025

Matusin Siti Nur Idayu, Mumin Nuramalina, Zainal Abidin Hazirah, Mohd Jaya Fatin Nurizzati, Lu Zen Huat, Haji Abdul Hamid Mas Rina Wati

Abstract excerpt

This is the first genetic study of its kind in Brunei Darussalam. BRCA1 and BRCA2 genes are the most well-known and well described predictors of hereditary breast cancer due to their clinical importance. This study aimed to identify the prevalence and mutation spectrum of the BRCA1 and BRCA2 germline mutations among 120 unselected series of Brunei breast cancer patients. We screened the entire coding region of...

Read the complete abstract on PubMed

Topics

Humans
Female
Germ-Line Mutation
Breast Neoplasms
Middle Aged
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

BRCA2 Protein

BRCA1 Protein

Brunei

Prevalence

Aged

Genetic Predisposition to Disease

Cohort Studies

Asian People

Source

Open in PubMed Open full text

Identifiers

PMID: 40531958
DOI: 10.1371/journal.pone.0312635
PMCID: PMC12176220

Genes

BRCA2
BRCA1

Provenance

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