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Article

Synergistic combination of two antimicrobial agents closing each other's mutant selection windows to prevent antimicrobial resistance.

Scientific reports - 8 May 2018

Xu Xuejie, Xu Li, Yuan Ganjun, Wang Yimin, Qu Yunqiu, Zhou Meijing

Abstract excerpt

Antimicrobial resistance seriously threatened human health. Combination therapy is generally an effective strategy to fight resistance, while some data on its effects are conflicting. To explore the reasons, the fractional inhibitory concentration indexes (FICIs) of three designed combinations against methicillin-resistant Staphylococcus aureus (MRSA) were determined using checkerboard method, and their minimal...

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Identifiers

PMID: 29740150
DOI: 10.1038/s41598-018-25714-z
PMCID: PMC5940791

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