Article
Protease-mediated activation of Par2 elicits calcium waves during zebrafish egg activation and blastomere cleavage.
PLoS biology - 1 Jun 2025
Ma Jiajia, Carney Tom J
Abstract excerpt
Successful initiation of animal development requires activation of the egg immediately prior to fusion of gamete pronuclei. In all taxa, this is initiated by waves of calcium transients which transverse across the egg. Calcium waves also occur at cleavage furrows during later blastula cytokinesis. Calcium is released from the endoplasmic reticulum through activation of inositol-1,4,5-trisphosphate (IP3)...
Read the complete abstract on PubMedTopics
- Animals
- Zebrafish
- Receptor, PAR-2
- Calcium Signaling
- Zebrafish Proteins
- Blastomeres
- Calcium