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Article

Subcellular localization of proline-rich tyrosine kinase 2 during oocyte fertilization and early-embryo development in mice

1 Jan 2016

Abstract excerpt

Proline-rich tyrosine kinase 2 (Pyk2), a non-receptor tyrosine kinase, is a member of the focal adhesion kinase family and is highly expressed in oocytes. Using a combination of confocal microscopy and RNAi, we localized and studied the function of both Pyk2 and tyrosine-phosphorylated Pyk2 (p-Pyk2) during mouse oocyte fertilization and early embryo development. At the onset of fertilization, Pyk2 and p-Pyk2 were...

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PMID: 27086609
DOI: 10.1262/jrd.2016-015

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