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Article

FARS2 deficiency in Drosophila reveals the developmental delay and seizure manifested by aberrant mitochondrial tRNA metabolism.

Nucleic acids research - 16 Dec 2021

Fan Wenlu, Jin Xiaoye, Xu Man, Xi Yongmei, Lu Weiguo, Yang Xiaohang, Guan Min-Xin, Ge Wanzhong

Abstract excerpt

Mutations in genes encoding mitochondrial aminoacyl-tRNA synthetases are linked to diverse diseases. However, the precise mechanisms by which these mutations affect mitochondrial function and disease development are not fully understood. Here, we develop a Drosophila model to study the function of dFARS2, the Drosophila homologue of the mitochondrial phenylalanyl-tRNA synthetase, and further characterize human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34878141
DOI: 10.1093/nar/gkab1187
PMCID: PMC8682739

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