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Article

Clinicopathological and molecular features of solid pseudopapillary neoplasms: a retrospective series including a small subset of aggressive cases.

Pathology oncology research : POR - 1 Jan 2026

Comut Erdem, Celik Ahmet, Uguz Alper, Ergun Orkan, Baran Simge, Argon Asuman, Nart Deniz, Yilmaz Funda, Demirkan Nese Calli

Abstract excerpt

Solid pseudopapillary neoplasms (SPNs) are rare pancreatic tumors that are indolent but occasionally present with metastatic or locally invasive disease. Although recurrent CTNNB1 exon 3 mutations define their molecular background, the clinicopathological and molecular features associated with these less common presentations remain incompletely characterized. This retrospective study included 62 patients...

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Identifiers

PMID: 41907195
DOI: 10.3389/pore.2026.1612367
PMCID: PMC13022977

Genes

AR
BAP1
CTNNB1
CDKN2A
SPN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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