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EZH2 inhibition and 5-azacytidine enhance antitumor immunity in PTEN-deficient glioblastoma by activation viral mimicry response

1 Jun 2025

Abstract excerpt

BACKGROUND: PTEN-deficient glioblastoma (GBM) is characterized by an immunosuppressive tumor microenvironment (TME), therapeutic resistance, and poor prognosis. Emerging evidence suggests that dysregulation of the endogenous retrovirus (ERV)-MAVS-IFN pathway may contribute to immune evasion in cancer, but its role in PTEN-deficient GBM remains unclear. METHODS: Using flow cytometry and single-cell RNA sequencing,...

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PMID: 40514071
DOI: 10.1136/jitc-2025-011650

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