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Article

Insights into structure and activity relationship of clinically mutated PER1 and PER2 class A β-lactamase enzymes.

Journal of biomolecular structure & dynamics - 1 Jul 2023

Agarwal Vidhu, Yadav Tara Chand, Tiwari Akhilesh, Varadwaj Pritish Kumar

Abstract excerpt

PER1 and PER2 are among the class A β-lactamase enzymes, which have evolved clinically to form antibiotic resistance and have significantly expanded their spectrum of activity. Hence, there is a need to study the clinical mutation responsible for such β-lactamase mediated antibiotic resistance. Alterations in catalytic centre and Ω-loop structure could be the cause of antibiotic resistance in these β-lactamase...

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Identifiers

PMID: 35475497
DOI: 10.1080/07391102.2022.2066179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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