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A map of blood regulatory variation in South Africans enables GWAS interpretation

11 Jun 2025

Abstract excerpt

Functional genomics resources are critical for interpreting human genetic studies, but currently they are predominantly from European-ancestry individuals. Here we present the South African Blood Regulatory (SABR) resource, a map of blood regulatory variation that includes three South Eastern Bantu-speaking groups. Using paired whole-genome and blood transcriptome data from over 600 individuals, we map the...

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PMID: 40500424
DOI: 10.1038/s41588-025-02223-0

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