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Potential roles of gut microbial tryptophan metabolites in the complex pathogenesis of acne vulgaris

27 Jul 2022

Abstract excerpt

Acne vulgaris is a chronic inflammatory skin disease in which the influence of gut microbiota has been implicated but without clarification of mechanisms. Gut microbiota may exert such an influence via metabolites, particularly those of tryptophan. End metabolites of tryptophan activate receptors, including aryl hydrocarbon, G protein-coupled, and pregnane X receptors to stabilize the immune microenvironment and...

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PMID: 35966699
DOI: 10.3389/fmicb.2022.942027

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