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Article

Polygenic prediction of cellular immune responses to mumps vaccine.

Genes and immunity - 1 Aug 2025

Coombes Brandon J, Ovsyannikova Inna G, Schaid Daniel J, Warner Nathaniel D, Poland Gregory A, Kennedy Richard B

Abstract excerpt

In this report, we provide a follow-up analysis of a previously published genome-wide association study (GWAS) evaluating the effect of genetic polymorphisms on inter-individual variations in cell-mediated immune responses to mumps vaccine. Here we report the results of a polygenic score (PGS) analysis showing how common variants can predict mumps vaccine response. We found higher PGS for IFNγ, IL-2, and TNFα...

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PMID: 40494895
DOI: 10.1038/s41435-025-00335-5

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