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SAE1 promotes tumor cell malignancy via SUMOylation and liquid–liquid phase separation facilitated nuclear export of p27

18 Feb 2025

Abstract excerpt

Most cancers are currently incurable, partly due to abnormal post-translational modifications (PTMs). In this study, we initially used multiple myeloma (MM) as a working model and found that SUMOylation activating enzyme subunit 1 (SAE1) promotes the malignancy of MM. Through proteome microarray analysis, SAE1 was identified as a potential target for bioactive colcemid or its derivative colchicine. Elevated...

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PMID: 40486843
DOI: 10.1016/j.apsb.2025.02.011

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