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Article

The polymorphic proteins TgrB1 and TgrC1 function as a ligand-receptor pair in Dictyostelium allorecognition.

Journal of cell science - 1 Dec 2017

Hirose Shigenori, Chen Gong, Kuspa Adam, Shaulsky Gad

Abstract excerpt

Allorecognition is a key factor in Dictyostelium development and sociality. It is mediated by two polymorphic transmembrane proteins, TgrB1 and TgrC1, which contain extracellular immunoglobulin domains. TgrB1 and TgrC1 are necessary and sufficient for allorecognition, and they carry out separate albeit overlapping functions in development, but their mechanism of action is unknown. Here, we show that TgrB1 acts as...

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Identifiers

PMID: 29038229
DOI: 10.1242/jcs.208975
PMCID: PMC5769593

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