Article
Hypermutable hotspot enables the rapid evolution of self/non-self recognition genes in Dictyostelium.
Proceedings of the National Academy of Sciences of the United States of America - 23 Dec 2025
Holland Mische, Ahmed Mayar, Young Janet M, Drurey James R, McFadyen Sean, Ostrowski Elizabeth A, Levin Tera C
Abstract excerpt
Cells require highly polymorphic receptors to perform accurate self/non-self recognition. In the amoeba Dictyostelium discoideum, polymorphic TgrB1 and TgrC1 proteins are used to bind sister cells and exclude cheaters, but it remains unknown how cells continually generate their extreme genetic diversity. Here, we created a collection of chromosome-length, whole genome sequences from 10 D. discoideum isolates and...
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