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Article

Evaluating genotype-treatment interactions for high-risk medications in British general practice: a retrospective cohort study using UK Biobank.

The British journal of general practice : the journal of the Royal College of General Practitioners - 1 Feb 2026

Mokbel Kinan, Weedon Michael, Daniels Rob, Moye Victoria, Jackson Leigh

Abstract excerpt

BACKGROUND: Pharmacogenetics has the potential to optimise drug therapy and reduce adverse drug effects (ADEs) by tailoring treatment to a patient's genotype, particularly for chronic disorders managed in general practice. However, the adoption of pharmacogenetics in general practice remains slow. AIM: To evaluate the reproducibility of previously reported associations between genomic variants and medically...

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Identifiers

PMID: 40473432
DOI: 10.3399/BJGP.2024.0806
PMCID: PMC13044196

Genes

SLCO1B1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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