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Article

Use of Drugs With Actionable Pharmacogenetic Biomarkers and Possible Prescribing Changes Among Older People.

Journal of the American Geriatrics Society - 1 Dec 2025

Zhao Zinan, Zhao Yuxuan, Hu Xiaowen, Wang Xue, Wang Gengchen, Zhang Xinyi, Dong Wenliang, Shi Luwen, Guan Xiaodong, Lu Christine Y, Jin Pengfei, Nie Xiaoyan

Abstract excerpt

BACKGROUND: Pharmacogenetic testing offers a pathway to safer prescribing and improved outcomes in older adults, who face heightened risks of adverse drug reactions due to polypharmacy and age-related metabolic changes. This study evaluates the prevalence of actionable pharmacogenetic biomarker use and estimates the potential impact of genotype-guided dosing in Chinese older adults. METHODS: This retrospective...

Topics

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Biomarkers
China
Cross-Sectional Studies
Cytochrome P-450 CYP2C19
Liver-Specific Organic Anion Transporter 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pharmacogenetics

Pharmacogenomic Testing

Practice Patterns, Physicians'

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Open in PubMed Open full text

Identifiers

PMID: 41017291
DOI: 10.1111/jgs.70126
PMCID: PMC12748018

Genes

CYP2C19
SLCO1B1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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