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Article

Integrating TWAS and GWAS identifies gut microbiota-immune interactions to alcohol dependence genetics in European sample.

Alcohol (Fayetteville, N.Y.) - 1 Sept 2025

Xu Haohao, Shen Peng, Zhao Zhenglin, Xing Yushuang, Yi Tonghui, Yang Chao, Gao Han, Guo Hongyan, Zhao Mingqian, Zhang Shanbo, Jia Di, Zhao Weiming

Abstract excerpt

OBJECTIVE: Alcohol dependence (AD) is a global public health concern with strong genetic characteristics. The purpose of this study was to explore the underlying pathogenic genes and mechanisms associated with AD. METHODS: This study employed a multi-omics Mendelian randomization approach to identify potential disease-causing genes for AD. Specifically, we integrated transcriptome-wide association studies (TWAS)...

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PMID: 40466958
DOI: 10.1016/j.alcohol.2025.05.006

Genes

ADH1C
POLI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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