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Article

Interplays of ADH1B Genotype, Alcohol Consumption, and Gut Microbiota in Relation to Insulin Resistance.

Nutrients - 18 Aug 2025

Wang Brian, Peters-Samuelson Brandilyn A, Luo Kai, Cordero Christina, Perreira Krista M, Pirzada Amber, Daviglus Martha L, Li Yang, Kaplan Robert C, Burk Robert D, Qi Qibin

Abstract excerpt

BACKGROUND/OBJECTIVE: Alcohol consumption has been linked to alterations in gut microbiota and insulin resistance. The alcohol dehydrogenase 1B (ADH1B) gene plays a crucial role in alcohol catabolism, where rs1229984 variant carriers (CT/TT) catabolize ethanol at an 80-fold faster rate than non-carriers (CC). This study investigates the relationships between ADH1B gene rs1229984 mutation, alcohol consumption, gut...

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Source

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Identifiers

PMID: 40871697
DOI: 10.3390/nu17162669
PMCID: PMC12389023

Genes

ADH1B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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