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Article

Genetic background influences susceptibility to exencephaly in Scavenger receptor Class B type 1-deficient mouse embryos.

Placenta - 1 Jan 2026

Romero-Muñoz Camila, Romo-Toledo Patricia, Belledonne Gabriela, Busso Dolores

Abstract excerpt

INTRODUCTION: Neural tube defects (NTD) are congenital malformations influenced by genetic and environmental factors. Mouse embryos deficient in Scavenger Receptor Class B Type 1 (SR-B1) exhibit female-skewed cranial NTD (exencephaly). This defect is preventable by maternal vitamin E supplementation in a C57BL/6J:129S1/SvImJ (B6:129) 1:1 background. In humans, genetic variability-such as differences across races...

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Genetic Background
Mice
Mice, Inbred C57BL
Mice, Knockout
Neural Tube Defects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Scavenger Receptors, Class B

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PMID: 40442009
DOI: 10.1016/j.placenta.2025.05.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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