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Article

Motor dexterity in schizophrenia spectrum disorders: Familiality and association with polygenic risk scores.

Progress in neuro-psychopharmacology & biological psychiatry - 20 Jun 2025

Sevilla-Ramos Manuel, Ladera Valentina, García-García Ricardo, Murillo-García Nancy, Ayesa-Arriola Rosa

Abstract excerpt

OBJECTIVE: Motor dexterity (MD), a potential endophenotype for schizophrenia spectrum disorders, might exhibit familiality, showing greater similarity among biological relatives. Moreover, MD deficits in first-episode psychosis (FEP) patients may be related to their increased genetic liability for schizophrenia (SCZ). We examined MD familiality and its association with genetic risk for SCZ. We controlled disorder...

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PMID: 40436363
DOI: 10.1016/j.pnpbp.2025.111406

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