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Article

Polo-like kinase 1 inactivation enhances PI3K inhibition-mediated apoptosis of NOTCH1-mutant head and neck squamous cell carcinoma.

Cancer letters - 10 Aug 2025

Shah Pooja A, Mazumdar Tuhina, Ghosh Soma, Yapindi Lacin, Powell Reid T, Park Yong S, Shen Li, Fernandez Anne M, Stephan Clifford C, Wang Jing, Sikora Andrew G, Kazi Jawad, Frederick Mitchell J, Johnson Faye M

Abstract excerpt

PI3K inhibition causes apoptosis selectively in NOTCH1-mutant head and neck squamous cell carcinoma (HNSCC), but modest single-agent responses and acquired resistance (AR) limit the clinical efficacy of targeted agents. To address these limitations, we investigated novel combination therapies. We tested the efficacy of 5768 compounds as single agents and 139 in combination with PI3K inhibitors in sensitive and AR...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40412794
DOI: 10.1016/j.canlet.2025.217814
PMCID: PMC13524226

Genes

PLK1
NOTCH1
AR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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