Mutagenicity studies with 5-thio-D-glucose. Cytogenetic investigation in mice, and the sex-linked recessive lethal gene test in Drosophila.

doi:10.1093/oxfordjournals.jhered.a109267

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Article

Mutagenicity studies with 5-thio-D-glucose. Cytogenetic investigation in mice, and the sex-linked recessive lethal gene test in Drosophila.

The Journal of heredity - 1 Jan 2000

Majumdar S K, Buchanan B, Feinstein S

Abstract excerpt

Cytogenetic studies in bone marrow cells and dividing spermatocytes I in male mice and the sex-linked recessive lethal gene test in Drosophila melanogaster were initiated to evaluate the mutagenic potential of 5-thio-D-glucose, a reversible male contraceptive in some mammals. The compound was administered by oral intubation to mice at 40 or 60 mg/kg for various time periods. Oregon-R D. melanogaster males were...

Topics

Animals
Bone Marrow
Chromosome Aberrations
Chromosomes
Drosophila melanogaster
Genes, Lethal
Genes, Recessive
Male
Mice
Mice, Inbred Strains
Mutagens

Mutation

Spermatogenesis

Thioglucosides

Thioglycosides

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