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Article

Common origin and somatic mutation patterns of composite lymphomas and leukemias.

Leukemia - 1 Aug 2025

Berg Victoria, Lollies Anna, Schneider Markus, Johansson Patricia, Weniger Marc A, Albertini Emma, Facchetti Fabio, Ascani Stefano, Moawia Abubakar, Bens Susanne, Fischer Anja, Siebert Reiner, Klapper Wolfram, Lorenzi Luisa, Tiacci Enrico, Hartmann Sylvia, Budeus Bettina, Hansmann Martin-Leo, Küppers Ralf

Abstract excerpt

When two lymphomas occur concurrently or sequentially in a patient, it is a major question whether they derive from the same lymphocyte or hematopoietic precursor cell or developed independently. We studied four composite classic Hodgkin lymphomas (HL) and other mature B-cell lymphomas, and two composite mature B- and T-cell neoplasias by whole exome sequencing (WES). Analysis of their IGV genes revealed that...

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Identifiers

PMID: 40404986
DOI: 10.1038/s41375-025-02549-y
PMCID: PMC12310529

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