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Article

Exome sequencing of Hodgkin and non-Hodgkin composite lymphomas identifies shared somatic mutations indicative of common founding precursors.

Cancer genetics - 1 Jun 2026

Gomez Felicia, Shea Lauren, Sharavanan Sivasankar Annamalai, Russler-Germain David, Mosior Matthew, Krysiak Kilannin, Matlock Matthew, Skidmore Zachary L, Lee Yi-Shan, Duncavage Eric J, O'Laughlin Michelle, Fronick Catrina, Fulton Robert S, Bartlett Nancy L, Cashen Amanda F, Griffith Malachi, Fehniger Todd A, Griffith Obi L, Wartman Lukas D

Abstract excerpt

The occurrence of both non-Hodgkin lymphoma (NHL) and classic Hodgkin lymphoma (cHL) in an individual patient (hereafter referred to as composite lymphoma) is a relatively rare and poorly characterized phenomenon. We hypothesized that analysis of the shared and divergent mutations harbored by composite lymphomas might shed light on genetic drivers of composite lymphomagenesis. We performed exome sequencing of two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41791303
DOI: 10.1016/j.cancergen.2026.02.007
PMCID: PMC13208115

Genes

IGH
BCL10
PCLO
PLCG2
SRSF6
TNFRSF14
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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