Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deterministic Lateral Displacement: The Next-Generation CAR T-Cell Processing?

SLAS technology - 1 Aug 2018

Campos-González Roberto, Skelley Alison M, Gandhi Khushroo, Inglis David W, Sturm James C, Civin Curt I, Ward Tony

Abstract excerpt

Reliable cell recovery and expansion are fundamental to the successful scale-up of chimeric antigen receptor (CAR) T cells or any therapeutic cell-manufacturing process. Here, we extend our previous work in whole blood by manufacturing a highly parallel deterministic lateral displacement (DLD) device incorporating diamond microposts and moving into processing, for the first time, apheresis blood products. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Component Removal
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Separation

Share to Immunotherapy, Adoptive

Share to Lymphocyte Activation

Share to Microarray Analysis

Share to Receptors, Chimeric Antigen

Share to T-Lymphocytes

Source

Identifiers

PMID: 29361868
DOI: 10.1177/2472630317751214

Genes

DLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deterministic Lateral Displacement: The Next-Generation CAR T-Cell Processing?PMID 29361868Read ↗

Cell trajectory modulation: rapid microfluidic biophysical profiling of CAR T cell functional phenotypesSemantic proximity Read ↗

Automated, scaled, transposon-based production of CAR T cellsSemantic proximity Read ↗

Scalable and ultrafast CAR-T cell production using microfluidicsSemantic proximity Read ↗

Microfluidic T-Chip enables one-step clinical-scale T-cell purification from blood products for CAR T-cell manufacturingSemantic proximity Read ↗

Digital Magnetic Sorting for Fractionating Cell Populations with Variable Antigen Expression in Cell Therapy Process DevelopmentSemantic proximity Read ↗

Development of a 3-day manufacturing method to generate CD19-CD20-CD22 trispecific CAR T-cells from whole blood.Semantic proximity Read ↗

Programmable microparticles rewire CAR signaling to enable super-physiological expansion of human T cells <i>in vitro</i>Semantic proximity Read ↗

A closed, autologous bioprocess optimized for TCR-T cell therapiesSemantic proximity Read ↗

High-density microbioreactor process designed for automated point-of-care manufacturing of CAR T cellsSemantic proximity Read ↗

Phenotypic and functional attributes of lentivirus-modified CD19-specific human CD8+ central memory T cells manufactured at clinical scale.Semantic proximity Read ↗

Development of Ingenui-T, a Novel Vein-to-Vein Solution for Rapid Autologous CAR T-Cell Manufacturing Starting From Whole Blood, for the Treatment of Autoimmune DiseasesSemantic proximity Read ↗

Microfluidic Isolation of Circulating Tumor Cell Clusters by Size and AsymmetrySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.