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Integrating exosome wide associations study and Mendelian randomization identified causal miRNAs for type 2 diabetes mellitus and its complications

20 May 2025

Abstract excerpt

BACKGROUND: Type 2 diabetes mellitus (T2DM) and its complications, including diabetic lower extremity arterial disease (DLEAD) and diabetic foot (DF), impose significant health burdens worldwide. However, the differential expression of microRNAs (miRNAs) between T2DM and its complications and its causal effects remain poorly understood. METHODS: We conducted an exosome-wide association study (EWAS) comparing...

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PMID: 40394717
DOI: 10.1186/s13098-025-01725-5

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